AHCC Muaj nuj nqi
AHCC hmoov (Active Hexose Correlated Compound) yog ib qho kev ua si nrog lub luag haujlwm ntau yam tshuaj hexose, uas yog nplua nuj hauv kev noj zaub mov zoo-glucan khoom noj. Nws yog tsim tawm los ntawm mycelium ntawm Lentinula edodes ntawm Basidiomycete tsev neeg, thiab qhov no tsis yog qhov pom zoo tshuaj. Lub hom phiaj tseem ceeb ntawm AHCC hmoov yog txhawm rau txo ntshav siab me ntsis. Txawm li cas los xij, pab pawg tshawb xyuas ntawm University of Tokyo pom tias AHCC muaj kev cuam tshuam zoo rau lub cev tsis muaj zog. Hauv xyoo 1992, lawv tau tshaj tawm lawv cov kev tshawb fawb. Cov kws tshawb nrhiav pom tias AHCC ua tau zoo txhawb kev ua haujlwm ntawm cov kab mob tua neeg hauv lub cev (NK) hauv cov neeg mob cancer. Nws kuj ntxiv dag zog rau tus tua T hlwb thiab cytokines (interferon, IL-12, TNF-a). Vim tias nws lub zog ua kom tsis muaj zog, nws tau dhau los ua ib qho kev ua kom lub cev nyiam kom neeg nyiam thoob ntiaj teb.
AHCC thiab lub cev muaj zog tiv thaiv kab mob
AHCC txhawb kev tiv thaiv cellular tiv thaiv vim tias AHCC tuaj yeem qhib cov qe ntshav dawb, tshwj xeeb tshaj yog cov kab mob tua neeg hauv hlwb (NK hlwb) thiab macrophages. Cov kab mob tua neeg thiab cov macrophages tuaj yeem ncaj qha mus tua cov hlwb tsis zoo, cov kab mob kis tus kab mob, lossis cov kab mob txawv teb chaws thiab cov kab mob uas nkag rau hauv lub cev. Qee cov kev tshawb fawb pom tau tias cov txheej txheem yooj yim ntawm AHCC hmoov ua kom lub zog tiv thaiv kab mob yog tias nws tuaj yeem txhawb lub hlwb dendritic. Dendritic cells ntes thiab xa cov tshuaj ua kom antigens (cov protein ua rau muaj kabmob) thiab nqa mus rau lymphatic plab hnyuv siab raum (xws li tus po thiab lub qog ntshav). Cytokines secreted los ntawm dendritic cov hlwb ua rau lub cev tiv thaiv kab mob. Cov cell B thiab T cell (B lymphocytes thiab T lymphocytes) yog cov kis ntawm cov kabmob hauv lub cev, tab sis cov hlwb dendritic tswj lub luag haujlwm ntawm cov hlwb no.
AHCC thiab kev tiv thaiv kabmob
Cov pa oxygen tsis zoo (ROS) tuaj yeem ua rau cov ntaub so ntswg ua kom puas tsuaj thiab ua rau lub zog laus. Txoj kev tshawb fawb los ntawm Tokkyo University of Tshuaj siv lub zog muaj zog hu ua Ferric nitrilotriacetate los pib ua haujlwm oxidation. Thiab txoj kev tshawb fawb no qhia tau tias AHCC tuaj yeem tiv thaiv cov ntaub so ntswg los ntawm kev sim no ntawm cov nas. Ferric nitrilotriacetate (Ferric nitrilotriacetate) yog ib yam tshuaj lom neeg uas tuaj yeem ua rau mob qog nqaij hlav thiab ua rau ntau lub nruab nrog cev, tshwj xeeb tshaj yog daim siab thiab lub raum. Kev kho mob ua ntej nrog AHCC pom cov kev tiv thaiv hauv qab no:
(1) Ib qho tseem ceeb txo tau cov mob tso zis 8-OhdG: DNA oxidative kev nyuaj siab ntsuas thiab cov kev pheej hmoo rau mob qog noj ntshav, mob ntshav qab zib thiab ntshav qab zib;
(2) Ua kom cov creatinine ua tau raws cov qauv, creatinine yog qhov ntsuas kev puas tsuaj ntawm lub raum;
(3) Qhov tseem ceeb txo AST thiab ALT ntshiab, uas yog qhov ntsuas ntawm daim siab puas;
(4) Txo cov thymocyte apoptosis, uas yog qhov ntsuas pom ntawm kev tiv thaiv kev tiv thaiv kab mob.
Cov txiaj ntsig no tau qhia tias muaj ntau yam thiab qib siab ntawm kev tiv thaiv oxidative kev nyuaj siab tuaj yeem ua tiav. Hauv lwm txoj kev tshawb nrhiav siv Ferric nitrilotriacetate, AHCC hmoov siv cov khoom siv antioxidant ntawm cov tshuaj tiv thaiv oxygen (ROS) los tiv thaiv kev txo qis ntawm thyroxine thiab testosterone ntau lawm.
