Cepharanthine yog ib hom tshiab ntawm bacteriostatic siv dav. Nws yog cov poov xab hluavtaws uas muaj -intramolecular endostatin, uas yog nyob rau hauv chav kawm ntawm cov tshuaj tua kab mob, 7-AC-endostatin. Lawv yuav luag intolerant ntawm cov kab mob hlwb thiab ua lub luag haujlwm hauv tib neeg xaiv thaum lub sijhawm. Penicillin, tshuaj tua kab mob, tshuaj tua kab mob, thiab lwm yam yog dav siv. Yog li ntawd, nws yog qhov kom zoo dua ntawm kev kho mob siab, tsis muaj cov as-ham, thiabdav siv, thiab lub luag haujlwm tseem ceeb ntawm cov tshuaj tua kab mob. Nws yog niam txiv ore ntawm nuclear -7-hom penicillanic acid (7-ACA), thiab qhov sib txawv ntawm 6-hom penicillin, qhov txawv ntawm qhov no yog cov kab mob tuaj yeem ua rau penicillin enzymes.
Zoo ib yam li penicillin. Thaum ntxov xav tias lub luag haujlwm nkaus xwb yog inhibit transpeptidase thiab cuam tshuam nrog cov kab mob ntawm cov cell phab ntsa synthesis. Nws tau raug pom tias -lactam tebchaw kuj tuaj yeem khi rau cov proteins tshwj xeeb (-lactam binding proteins), uas tej zaum yuav yog, hauv cov ntsiab lus, qee cov enzymes ntawm cov cell membrane. Qhov no hloov cov permeability ntawm cov kab mob cell membranes, inhibits protein synthesis, thiab tso tawm autolysin, yog li nws muaj ib tug bacteriolytic nyhuv los yog ua rau nws loj hlob fibrous yam tsis muaj kev faib.
Nws tuaj yeem muab faib ua ntau yam hauv lub cev, yog li kev kis kab mob ntawm ntau cov ntaub so ntswg thiab lub cev tshwm sim; tsuav yog cov kab mob pathogenic rhiab heev, lawv tuaj yeem siv tau.
Nws yog cov tshuaj tua kab mob uas tuaj yeem tua cov kab mob yog tias nws txaus. Tsis zoo li cov kab mob bacteriostatic xws li tetracycline, erythromycin, thiab chloramphenicol, nws tsuas yog inhibits kev loj hlob ntawm cov kab mob ntawm cov koob tshuaj tsis tu ncua.
Yog li ntawd, lawv tuaj yeem siv rau cov kab mob hnyav dua.
Qhov zoo 1:Cov kab mob tua kab mob yog qhov dav, thiab lawv muaj cov kab mob zoo rau cov kab mob gram-positive thiab gram-negative.
Qhov zoo 2:Yog tias cov kab mob tsim qee cov enzymes uas rhuav tshem qee cov tshuaj tua kab mob, lawv tuaj yeem tiv taus qee cov tshuaj tua kab mob. Piv txwv li, cov kab mob no tiv taus penicillin, thiab lawv kuj ruaj khov rau feem ntau ntawm cov enzymes tsim los ntawm cov kab mob. Yuav hloov penicillin los tua cov kab mob.
Qhov zoo 3:Piv nrog rau penicillin, kev tsis haum tshuaj rau penicillin yog qhov siab, tshwj xeeb tshaj yog penicillin tuaj yeem ua rau anaphylactic shock thiab ua rau tuag taus.
Hauv xyoo tas los no, cov kab mob gram-zoo xws li Staphylococcus aureus, coagulase-negative staphylococcus, thiab hemolytic streptococcus tau nce. Nws tsis ruaj khov rau AmpC gene-related-lactamase, thiab nws tsuas yog kov yeej cov saum toj no Vim yog ob qho tsis txaus, nws tuaj yeem hloov cov ceftazidime thiab dhau los ua cov tshuaj xaiv rau kev kho mob empirical [1]
Nws muaj cov kab mob dav dav, ruaj khov rau -lactamase, muaj cov tshuaj ntshav siab ntau, thiab tuaj yeem nkag mus rau hauv cov ntshav-hlwb teeb meem. Cov txiaj ntsig ntawm daim ntawv thov kev kho mob ua ntej kuj tau pom qee qhov zoo tshaj ntawm cov tshuaj no.Cepharanthinecia siab tias hom tshuaj no yuav nkag mus rau hauv lub tebchaws sai sai. Nws daim ntawv thov tus nqi hauv chav ua pa thiab lwm lub chaw kho mob yuav tsum raug soj ntsuam los ntawm cov kws kho mob feem ntau.
