Pab pawg tshawb fawb txawv teb chaws luam tawm lub npe" Effect of Valerian Extract on GABRB3 Gene MRNA Expression and Sedation in BALB/C Mice&"; Hauv Tam Sim No Bioactive Compounds thaum Lub Kaum Ib Hlis 10, 2020. Tsab ntawv xov xwm tau qhia tias GABRB3 noob tom qab ua haujlwm ntawm Valerian extract mRNA kev qhia tau nce ntxiv, thiab valerian extract thiab diazepam muaj cov tshuaj zoo sib xws.
Valerianyog cov tshuaj ntsuab muaj hnub nyoog tsim tawm hauv Europe thiab Asia. Nws tau faib dav hauv yuav luag txhua lub tebchaws uas cov av muaj acidic. Valerian tau siv hauv cov tshuaj ib txwm muaj los kho kev pw tsaug zog, ntxhov siab, qaug zog, qaug dab peg, qaug dab peg thiab qaug zog rau 2000 xyoo. Lub hauv paus tseem ceeb ntawm cov tshuaj valerian yog valeric acid uas muaj hydroxyl thiab acetone derivatives.
Valeric acid muaj kev tiv thaiv kev ntxhov siab, ua kom tsaug zog thiab ua kom tsaug zog, uas tau lees paub hauv kev tshawb fawb tsiaj thiab kev sim tshuaj. Valeric acid inhibits decomposition γ-aminobutyric acid (GABA) tshwm sim los ntawm catabolic enzymes hauv lub hlwb, yog li ua rau muaj txiaj ntsig sedative. Gamma-aminobutyric acid yog lub hlwb tseem ceeb tshaj plaws cuam tshuam rau kev xa cov neurotransmitter, uas ua lub luag haujlwm tseem ceeb hauv kev tswj hwm thiab ua haujlwm ntawm lub hauv paus paj hlwb. Cov nyhuv sedative ntawm valerian extract tau txhawb los ntawm GABAA receptor β3 subunit. GABRB3 noob belongs rau ligand-gated ion channel tsev neeg thiab nkag mus rau β3 subunit ntawm GABAA receptor. GABRB3 kuj tseem yog tus txais rau diazepam thiab lwm yam tshuaj loog (piv txwv li, phenobarbital).
Valerian cuam tshuam rau cov khoom siv presynaptic ntawm GABAergic neurons, thiab cov khoom no cuam tshuam rau kev tso tawm ntawm synaptic GABA. Valerian tseem txwv qhov rov ua dua thiab catabolism ntawm γ-aminobutyric acid los ntawm kev txwv γ-aminobutyric acid transaminase.
